Expression analysis of aldehyde dehydrogenase 1A1 (ALDH1A1) in colon and rectal cancer in association with prognosis and response to chemotherapy
2012-12 | journal article; research paper
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Expression analysis of aldehyde dehydrogenase 1A1 (ALDH1A1) in colon and rectal cancer in association with prognosis and response to chemotherapy
Kahlert, C.; Gaitzsch, E.; Steinert, G.; Mogler, C.; Herpel, E.; Hoffmeister, M. & Jansen, L. et al. (2012)
Annals of Surgical Oncology, 19(13) pp. 4193-4201. DOI: https://doi.org/10.1245/s10434-012-2518-9
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Details
- Authors
- Kahlert, Christoph; Gaitzsch, Eva; Steinert, Gunnar; Mogler, Carolin; Herpel, Esther; Hoffmeister, Michael; Jansen, Lina; Benner, Axel; Brenner, Hermann; Chang-Claude, Jenny; Rahbari, Nuh; Schmidt, Thomas; Klupp, Fee; Grabe, Niels ; Lahrmann, Bernd; Koch, Moritz; Halama, Niels; Büchler, Markus; Weitz, Juergen
- Abstract
- Aldehyde dehydrogenase 1A1 (ALDH1A1) has been described as a cancer stem cell marker and as a regulator of cellular chemoresistance. Therefore, ALDH1A1 has been suggested as potential biomarker to stratify patients into different risk categories for a "personalized" therapy approach. We have investigated the prognostic role of ALDH1A1 in primary colorectal cancer and its value in predicting response to chemotherapy in metastatic colorectal cancer.
- Issue Date
- December-2012
- Journal
- Annals of Surgical Oncology
- ISSN
- 1068-9265
- eISSN
- 1534-4681
- Language
- English
