Hyperpolarization of 15 N in an amino acid derivative
2022 | journal article. A publication with affiliation to the University of Göttingen.
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- Authors
- Saul, Philip; Mamone, Salvatore; Glöggler, Stefan
- Abstract
- A perdeuterated, 15 N-labeled derivative of the amino acid glycine has been synthesized and polarized by means of para -hydrogen induced polarization (PHIP).
Hyperpolarization is a nuclear magnetic resonance (NMR) technique which can be used to significantly enhance the signal in NMR experiments. In recent years, the possibility to enhance the NMR signal of heteronuclei by the use of para -hydrogen induced polarization (PHIP) has gained attention, especially in the area of possible applications in magnetic resonance imaging (MRI). Herein we introduce a way to synthesize a fully deuterated, 15 N labelled amino acid derivative and the possibility to polarize the 15 N by means of hydrogenation with para -hydrogen to a polarization level of 0.18%. The longevity of the polarization with a longitudinal relaxation time of more than a minute can allow for the observation of dynamic processes and metabolic imaging in vivo . In addition, we observe the phenomenon of proton–deuterium exchange with a homogeneous catalyst leading to signal enhanced allyl moeities in the precursor.
A perdeuterated, 15 N-labeled derivative of the amino acid glycine has been synthesized and polarized by means of para -hydrogen induced polarization (PHIP).
Hyperpolarization is a nuclear magnetic resonance (NMR) technique which can be used to significantly enhance the signal in NMR experiments. In recent years, the possibility to enhance the NMR signal of heteronuclei by the use of para -hydrogen induced polarization (PHIP) has gained attention, especially in the area of possible applications in magnetic resonance imaging (MRI). Herein we introduce a way to synthesize a fully deuterated, 15 N labelled amino acid derivative and the possibility to polarize the 15 N by means of hydrogenation with para -hydrogen to a polarization level of 0.18%. The longevity of the polarization with a longitudinal relaxation time of more than a minute can allow for the observation of dynamic processes and metabolic imaging in vivo . In addition, we observe the phenomenon of proton–deuterium exchange with a homogeneous catalyst leading to signal enhanced allyl moeities in the precursor. - Issue Date
- 2022
- Journal
- RSC Advances
- eISSN
- 2046-2069
- Language
- English