Aspirin improves transplant-free survival after TIPS implantation in patients with refractory ascites: a retrospective multicentre cohort study
2022 | journal article; research paper. A publication with affiliation to the University of Göttingen.
Jump to: Cite & Linked | Documents & Media | Details | Version history
Cite this publication
Aspirin improves transplant-free survival after TIPS implantation in patients with refractory ascites: a retrospective multicentre cohort study
Seifert, L. L.; Schindler, P.; Sturm, L.; Gu, W.; Seifert, Q. E. ; Weller, J. F. & Jansen, C. et al. (2022)
Hepatology International,. DOI: https://doi.org/10.1007/s12072-022-10330-x
Documents & Media
Details
- Authors
- Seifert, Leon Louis; Schindler, Philipp; Sturm, Lukas; Gu, Wenyi; Seifert, Quentin Edward ; Weller, Jan Frederic; Jansen, Christian; Praktiknjo, Michael; Meyer, Carsten; Schoster, Martin; Heinzow, Hauke
- Abstract
- Abstract Background and aims Transjugular intrahepatic portosystemic shunt (TIPS) implantation is an established procedure to treat portal hypertension. Impact of administration of aspirin on transplant-free survival after TIPS remains unknown. Methods A multicenter retrospective analysis including patients with TIPS implantation between 2011 and 2018 at three tertiary German Liver Centers was performed. N = 583 patients were included. Survival analysis was performed in a matched cohort after propensity score matching. Patients were grouped according to whether aspirin was ( PSM-aspirin-cohort ) or was not ( PSM-no-aspirin-cohort ) administered after TIPS. Primary endpoint of the study was transplant-free survival at 12 months after TIPS. Results Aspirin improved transplant-free survival 12 months after TIPS with 90.7% transplant-free survival compared to 80.0% ( p = 0.001) after PSM. Separated by TIPS indication, aspirin did improve transplant-free survival in patients with refractory ascites significantly (89.6% vs. 70.6% transplant-free survival, p < 0.001), while no significant effect was observed in patients with refractory variceal bleeding (91.1% vs. 92.2% transplant-free survival, p = 0.797). Conclusion This retrospective multicenter study provides first data indicating a beneficial effect of aspirin on transplant-free survival after TIPS implantation in patients with refractory ascites.
- Issue Date
- 2022
- Journal
- Hepatology International
- Organization
- Professur für Raumbezogene Datenanalyse und Statistische Lernverfahren
- ISSN
- 1936-0533
- eISSN
- 1936-0541
- Language
- English