Defining the Mammalian Peroxisomal Proteome
2018 | book part
Jump to: Cite & Linked | Documents & Media | Details | Version history
Cite this publication
Defining the Mammalian Peroxisomal Proteome
Yifrach, E.; Fischer, S.; Oeljeklaus, S.; Schuldiner, M. ; Zalckvar, E.& Warscheid, B. (2018)
In: Proteomics of Peroxisomes. Identifying Novel Functions and Regulatory Networks pp. 47-66. (Vol. 89). Singapore: Springer. DOI: https://doi.org/10.1007/978-981-13-2233-4_2
Documents & Media
Details
- Authors
- Yifrach, Eden; Fischer, Sven; Oeljeklaus, Silke; Schuldiner, Maya ; Zalckvar, Einat; Warscheid, Bettina
- Abstract
- The current view on peroxisomes has changed dramatically from being human cell oddities to vital organelles that host several key metabolic pathways. To fulfil over 50 different enzymatic functions, human peroxisomes host either unique peroxisomal proteins or dual-localized proteins. The identification and characterization of the complete peroxisomal proteome in humans is important for diagnosis and treatment of patients with peroxisomal disorders as well as for uncovering novel peroxisomal functions and regulatory modules. Hence, here we compiled a comprehensive list of mammalian peroxisomal and peroxisome-associated proteins by curating results of several quantitative and non-quantitative proteomic studies together with entries in the UniProtKB and Compartments knowledge channel databases. Our analysis gives a holistic view on the mammalian peroxisomal proteome and brings to light potential new peroxisomal and peroxisome-associated proteins. We believe that this dataset, represents a valuable surrogate map of the human peroxisomal proteome.
- Issue Date
- 2018
- Publisher
- Springer
- Project
- SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente
SFB 1190 | P11: Zuordnung zellulärer Kontaktstellen und deren Zusammenspiel - Working Group
- RG Schuldiner (Functional Genomics of Organelles)
- ISBN
- 978-981-13-2232-7
978-981-13-2233-4 - Language
- English