Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia
2022-10 | journal article; research paper
Jump to: Cite & Linked | Documents & Media | Details | Version history
Cite this publication
Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia
Teller, J.; Jung, C.; Wilke, J. B. H.; Schimmelpfennig, S.-D.; Hindermann, M.; Hinken, L. & Gabriel, M. M. et al. (2022)
Brain, behavior, & immunity - health, 24 art. 100494. DOI: https://doi.org/10.1016/j.bbih.2022.100494
Documents & Media
Details
- Authors
- Teller, Johannes; Jung, Carolin; Wilke, Justus B. H.; Schimmelpfennig, Svea-Dorothée; Hindermann, Martin; Hinken, Lukas; Gabriel, Maria M.; Fegbeutel, Christine; Schäfer, Andreas; Laser, Hans; Lichtinghagen, Ralf; Worthmann, Hans; Weissenborn, Karin; Ehrenreich, Hannelore
- Abstract
- Anesthetics penetrate the blood-brain-barrier (BBB) and - as confirmed preclinically - transiently disrupt it. An analogous consequence in humans has remained unproven. In mice, we previously reported that upon BBB dysfunction, the brain acts as 'immunoprecipitator' of autoantibodies against N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1-AB). We thus hypothesized that during human anesthesia, pre-existing NMDAR1-AB will specifically bind to brain. Screening of N = 270 subjects undergoing general anesthesia during cardiac surgery for serum NMDAR1-AB revealed N = 25 NMDAR1-AB seropositives. Only N = 14 remained positive post-surgery. No changes in albumin, thyroglobulin or CRP were associated with reduction of serum NMDAR1-AB. Thus, upon anesthesia, BBB opening likely occurs also in humans.
- Issue Date
- October-2022
- Journal
- Brain, behavior, & immunity - health
- Project
- TRR 274: Checkpoints of Central Nervous System Recovery
TRR 274 | C01: Oligodendroglial NMDA receptors and NMDAR1 autoantibodies as determinants of axonal integrity in neuropsychiatric disease - Working Group
- RG Ehrenreich (Clinical Neuroscience)
- eISSN
- 2666-3546
- Language
- English
