pH-Dependent fluorescence of [La(OH)2]+[ARS]− hybrid nanoparticles for intracellular pH-sensing
2022 | journal article. A publication with affiliation to the University of Göttingen.
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- Authors
- Sabljo, Kristina; Napp, Joanna ; Alves, Frauke ; Feldmann, Claus
- Abstract
- Saline inorganic–organic hybrid nanoparticles (IOH-NPs) [La(OH)2]+[ARS]− (ARS: alizarin red S) are prepared in water as a new compound (particle size: 47 ± 7 nm, ARS load: 65 wt%). The IOH-NPs not only show a pH-dependent absorption colour but also a pH-dependent fluorescence with green emission at pH 5.0–9.0 and red emission at pH < 4.5. According to first in vitro studies, the pH-dependend fluorescence can be used to monitor nanoparticle internalization in cells as well as the respective intracellular pH. − inorganic–organic hybrid nanoparticles (ARS: alizarin red S) exhibit pH-dependent absorption and pH-dependent emission, allowing to monitor nanoparticle internalization in cells and the intracellular pH.
- Issue Date
- 2022
- Journal
- Chemical Communications
- Organization
- Institut für Diagnostische und Interventionelle Radiologie ; Universitätsmedizin Göttingen ; Max-Planck-Institut für Multidisziplinäre Naturwissenschaften
- Working Group
- RG Alves (Translationale Molekulare Bildgebung)
- ISSN
- 1359-7345
- eISSN
- 1364-548X
- Language
- English
- Sponsor
- Deutsche Forschungsgemeinschaft https://doi.org/10.13039/501100001659