From Disorder to Normal Rhythm: Traveling-Wave Control of Cardiac Arrhythmias
2022 | journal article. A publication with affiliation to the University of Göttingen.
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Details
- Authors
- Majumder, Rupamanjari; Zykov, Vladimir S.; Bodenschatz, Eberhard
- Abstract
- Lethal cardiac arrhythmias often involve the occurrence of spiral waves, whose control is essential for the treatment of the disease. While high-voltage shock-based control methods rely on ensuring an abrupt electrical synchronization of the heart, low-energy techniques mostly cause drift-induced termination of these waves. In particular, such a drift can be induced by a spatiotemporal modulation of domain excitability in optogenetically modified cardiac tissue. Here we demonstrate a low-energy optogenetics-based approach to suppress spiral waves via their transient chaotization and rapid drift.
- Issue Date
- 2022
- Journal
- Physical Review Applied
- Organization
- Max-Planck-Institut für Dynamik und Selbstorganisation ; Institut für Dynamik komplexer Systeme
- eISSN
- 2331-7019
- Language
- English
- Sponsor
- Max Planck Society http://dx.doi.org/10.13039/501100004189
German Center for Cardiovascular Research http://dx.doi.org/10.13039/100010447