Calcium in peroxisomes: An essential messenger in an essential cell organelle
2022 | journal article; overview. A publication with affiliation to the University of Göttingen.
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- Authors
- Sargsyan, Yelena; Kalinowski, Julia; Thoms, Sven
- Abstract
- Calcium is a central signal transduction element in biology. Peroxisomes are essential cellular organelles, yet calcium handling in peroxisomes has been contentious. Recent advances show that peroxisomes are part of calcium homeostasis in cardiac myocytes and therefore may contribute to or even shape their calcium-dependent functionality. However, the mechanisms of calcium movement between peroxisomes and other cellular sites and their mediators remain elusive. Here, we review calcium handling in peroxisomes in concert with other organelles and summarize the most recent knowledge on peroxisomal involvement in calcium dynamics with a focus on mammalian cells.
- Issue Date
- 2022
- Journal
- Frontiers in Cell and Developmental Biology
- Project
- SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz
SFB 1002 | A10: Peroxisomen als modulatorische Einheiten im Herzstoffwechsel und bei Herzinsuffizienz - Organization
- Deutsches Zentrum für Herz-Kreislauf-Forschung e.V. ; Klinik für Kinder- und Jugendmedizin ; Universitätsmedizin Göttingen
- Working Group
- RG Thoms (Biochemistry and Molecular Medicine)
- eISSN
- 2296-634X