Simultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterization
2022 | journal article. A publication with affiliation to the University of Göttingen.
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Simultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterization
Wurster, T. H.; Landmesser, U.; Abdelwahed, Y. S.; Skurk, C.; Morguet, A.; Leistner, D. M. & Fröhlich, G. et al. (2022)
European Heart Journal - Cardiovascular Imaging, 23(10) pp. 1391-1398. DOI: https://doi.org/10.1093/ehjci/jeab276
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Details
- Authors
- Wurster, Thomas H.; Landmesser, Ulf; Abdelwahed, Youssef S.; Skurk, Carsten; Morguet, Andreas; Leistner, David M.; Fröhlich, Georg; Haghikia, Arash; Engel, Leif Christopher; Schuster, Andreas ; Makowski, Marcus R.
- Abstract
- Abstract Aims 18F-sodium fluoride ([18F]fluoride) and gadobutrol are promising probes for positron emission tomography (PET) and magnetic resonance imaging (MRI) characterizing coronary artery disease (CAD) activity. Unlike [18F]fluoride-PET/computed tomography (CT), the potential of PET/MR using [18F]fluoride and gadobutrol simultaneously, has so far not been evaluated. This study assessed feasibility and diagnostic potential of [18F]fluoride and gadobutrol enhanced dual-probe PET/MR in patients with CAD. Methods and results Twenty-one patients (age, 66.7 ± 6.7 years) with CAD scheduled for invasive coronary angiography (XCA) underwent simultaneous [18F]fluoride (mean activity/effective dose: 157.2 ± 29.7 MBq/3.77 ± 0.72 mSv) and gadobutrol enhanced PET/MR on an integrated PET/MRI (3 T) scanner. Optical coherence tomography (OCT) was used as reference. Target-to-background ratio (TBR, [18F]fluoride-PET) and contrast-to-noise ratio (CNR) values (MRI, gadobutrol) were calculated for each coronary segment. Previously suggested PET/CT-TBR thresholds for adverse coronary events were evaluated. High-risk plaques, i.e. calcified and non-calcified thin-cap fibroatheromas (TCFAs) were predominantly located in segments with a TBR >1.28 (P = 0.012). Plaques containing a lipid core on OCT, were more frequently detected in segments with a TBR >1.25 (P < 0.001). TBR values significantly correlated with maximum calcification thickness (P = 0.009), while fibrous cap thickness was significantly less in segments with a TBR >1.28 (P = 0.044). Above a TBR threshold of >1.28, CNR values significantly correlated with the presence of calcified TCFAs (P = 0.032). Conclusion Simultaneous [18F]fluoride and gadobutrol dual-probe PET/MRI is feasible in clinical practice and may facilitate the identification of high-risk patients. The combination of coronary MR-derived CNR values post gadobutrol and [18F]fluoride based TBR values may improve identification of high-risk plaque features.
- Issue Date
- 2022
- Journal
- European Heart Journal - Cardiovascular Imaging
- Organization
- Klinik für Kardiologie und Pneumologie
- ISSN
- 2047-2404
- eISSN
- 2047-2412
- Language
- English