Risk of Immunodeficiency Virus Infection May Increase with Vaccine-Induced Immune Response
2012 | journal article
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Risk of Immunodeficiency Virus Infection May Increase with Vaccine-Induced Immune Response
Tenbusch, M.; Ignatius, R.; Temchura, V.; Nabi, G.; Tippler, B.; Stewart-Jones, G. & Salazar, A. M. et al. (2012)
Journal of Virology, 86(19) pp. 10533-10539. DOI: https://doi.org/10.1128/JVI.00796-12
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Details
- Authors
- Tenbusch, Matthias; Ignatius, Ralf; Temchura, Vladimir; Nabi, Ghulam; Tippler, Bettina; Stewart-Jones, Guillaume; Salazar, Andres M.; Sauermann, Ulrike; Stahl-Hennig, Christiane; Überla, Klaus
- Abstract
- ABSTRACT To explore the efficacy of novel complementary prime-boost immunization regimens in a nonhuman primate model for HIV infection, rhesus monkeys primed by different DNA vaccines were boosted with virus-like particles (VLP) and then challenged by repeated low-dose rectal exposure to simian immunodeficiency virus (SIV). Characteristic of the cellular immune response after the VLP booster immunization were high numbers of SIV-specific, gamma interferon-secreting cells after stimulation with inactivated SIV particles, but not SIV peptides, and the absence of detectable levels of CD8 + T cell responses. Antibodies specific to SIV Gag and SIV Env could be induced in all animals, but, consistent with a poor neutralizing activity at the time of challenge, vaccinated monkeys were not protected from acquisition of infection and did not control viremia. Surprisingly, vaccinees with high numbers of SIV-specific, gamma interferon-secreting cells were infected fastest during the repeated low-dose exposures and the numbers of these immune cells in vaccinated macaques correlated with susceptibility to infection. Thus, in the absence of protective antibodies or cytotoxic T cell responses, vaccine-induced immune responses may increase the susceptibility to acquisition of immunodeficiency virus infection. The results are consistent with the hypothesis that virus-specific T helper cells mediate this detrimental effect and contribute to the inefficacy of past HIV vaccination attempts (e.g., STEP study).
- Issue Date
- 2012
- Journal
- Journal of Virology
- Organization
- Deutsches Primatenzentrum
- ISSN
- 0022-538X
- eISSN
- 1098-5514
- Language
- English