Remote C−H Glycosylation by Ruthenium(II) Catalysis: Modular Assembly of meta‐C‐Aryl Glycosides
2022-09-13 | journal article. A publication with affiliation to the University of Göttingen.
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Remote C−H Glycosylation by Ruthenium(II) Catalysis: Modular Assembly of meta‐C‐Aryl Glycosides
Wu, J.; Kaplaneris, N.; Pöhlmann, J.; Michiyuki, T.; Yuan, B. & Ackermann, L. (2022)
Angewandte Chemie International Edition, 61(42) art. anie.202208620. DOI: https://doi.org/10.1002/anie.202208620
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Details
- Authors
- Wu, Jun; Kaplaneris, Nikolaos; Pöhlmann, Julia; Michiyuki, Takuya; Yuan, Binbin; Ackermann, Lutz
- Abstract
- Abstract
The prevalence of C‐aryl glycosides in biologically active natural products and approved drugs has long motivated the development of efficient strategies for their selective synthesis. Cross‐couplings have been frequently used, but largely relied on palladium catalyst with prefunctionalized substrates, while ruthenium‐catalyzed C‐aryl glycoside preparation has thus far proven elusive. Herein, we disclose a versatile ruthenium(II)‐catalyzed meta‐C−H glycosylation to access meta‐C‐aryl glycosides from readily available glycosyl halide donors. The robustness of the ruthenium catalysis was reflected by mild reaction conditions, outstanding levels of anomeric selectivity and exclusive meta‐site‐selectivity.
A ruthenium(II)/phosphine catalysis system enabled versatile meta‐arene C−H glycosylation by σ‐activation. Thus, easily accessible glycosyl bromide donors furnished 1,2‐trans C‐aryl glycosides via robust ruthenium(II) catalysis under exceedingly mild conditions. image - Issue Date
- 13-September-2022
- Journal
- Angewandte Chemie International Edition
- Organization
- Institut für Organische und Biomolekulare Chemie ; Friedrich-Wöhler-Forschungsinstitut für Nachhaltige Chemie
- ISSN
- 1433-7851
- eISSN
- 1521-3773
- Language
- English
- Sponsor
- European Research Council http://dx.doi.org/10.13039/501100000781
DFG http://dx.doi.org/10.13039/501100001659
CSC
H2020 Marie Skłodowska-Curie Actions http://dx.doi.org/10.13039/100010665