SARS-CoV-2 infects human cardiomyocytes promoted by inflammation and oxidative stress
2022 | journal article. A publication with affiliation to the University of Göttingen.
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SARS-CoV-2 infects human cardiomyocytes promoted by inflammation and oxidative stress
Tangos, M.; Budde, H.; Kolijn, D.; Sieme, M.; Zhazykbayeva, S.; Lódi, M. & Herwig, M. et al. (2022)
International Journal of Cardiology, 362 pp. 196-205. DOI: https://doi.org/10.1016/j.ijcard.2022.05.055
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Details
- Authors
- Tangos, Melina; Budde, Heidi; Kolijn, Detmar; Sieme, Marcel; Zhazykbayeva, Saltanat; Lódi, Mária; Herwig, Melissa; Gömöri, Kamilla; Hassoun, Roua; Robinson, Emma Louise; Hamdani, Nazha
- Abstract
- Introduction The respiratory illness triggered by severe acute respiratory syndrome virus-2 (SARS-CoV-2) is often particularly serious or fatal amongst patients with pre-existing heart conditions. Although the mechanisms underlying SARS-CoV-2-related cardiac damage remain elusive, inflammation (i.e. ‘cytokine storm’) and oxidative stress are likely involved. Methods and results Here we sought to determine: 1) if cardiomyocytes are targeted by SARS-CoV-2 and 2) how inflammation and oxidative stress promote the viral entry into cardiac cells. We analysed pro-inflammatory and oxidative stress and its impact on virus entry and virus-associated cardiac damage from SARS-CoV-2 infected patients and compared it to left ventricular myocardial tissues obtained from non-infected transplanted hearts either from end stage heart failure or non-failing hearts (donor group). We found that neuropilin-1 potentiates SARS-CoV-2 entry into human cardiomyocytes, a phenomenon driven by inflammatory and oxidant signals. These changes accounted for increased proteases activity and apoptotic markers thus leading to cell damage and apoptosis. Conclusion This study provides new insights into the mechanisms of SARS-CoV-2 entry into the heart and defines promising targets for antiviral interventions for COVID-19 patients with pre-existing heart conditions or patients with co-morbidities.
- Issue Date
- 2022
- Journal
- International Journal of Cardiology
- Organization
- Klinik für Kardiologie und Pneumologie ; Deutsches Zentrum für Herz-Kreislauf-Forschung e.V. ; Universitätsmedizin Göttingen
- ISSN
- 0167-5273
- Language
- English