Large 31 P-NMR enhancements in liquid state dynamic nuclear polarization through radical/target molecule non-covalent interaction
2023 | journal article. A publication with affiliation to the University of Göttingen.
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Large 31 P-NMR enhancements in liquid state dynamic nuclear polarization through radical/target molecule non-covalent interaction
Reinhard, M.; Levien, M.; Bennati, M. & Orlando, T. (2023)
Physical Chemistry Chemical Physics, 25(1) pp. 822-828. DOI: https://doi.org/10.1039/D2CP04092A
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Details
- Authors
- Reinhard, Maik; Levien, Marcel; Bennati, Marina; Orlando, Tomas
- Abstract
- Large 31 P-NMR enhancements are observed with DNP in PPh 3 doped with BDPA radical, while they are reduced when a nitroxide radical or triphenylphosphine-oxide are used instead. This is due to different non-covalent radical/target molecule interactions.
Dynamic nuclear polarization (DNP) is a method to enhance the low sensitivity of nuclear magnetic resonance (NMR) via spin polarization transfer from electron spins to nuclear spins. In the liquid state, this process is mediated by fast modulations of the electron-nuclear hyperfine coupling and its efficiency depends strongly on the applied magnetic field. A peculiar case study is triphenylphosphine (PPh 3 ) dissolved in benzene and doped with BDPA radical because it gives 31 P-NMR signal enhancements of two orders of magnitude up to a magnetic field of 14.1 T. Here we show that the large 31 P enhancements of BDPA/PPh 3 in benzene at 1.2 T (i) decrease when the moieties are dissolved in other organic solvents, (ii) are strongly reduced when using a nitroxide radical, and (iii) vanish with pentavalent 31 P triphenylphosphine oxide. Those experimental observations are rationalized with numerical calculations based on density functional theory that show the tendency of BDPA and PPh 3 to form a weak complex via non-covalent interaction that leads to large hyperfine couplings to 31 P (Δ A iso ≥ 13 MHz). This mechanism is hampered in other investigated systems. The case study of 31 P-DNP in PPh 3 is an important example that extends the current understanding of DNP in the liquids state: non-covalent interactions between radical and target can be particularly effective to obtain large NMR signal enhancements. - Issue Date
- 2023
- Journal
- Physical Chemistry Chemical Physics
- ISSN
- 1463-9076
- eISSN
- 1463-9084
- Language
- English
- Sponsor
- Max-Planck-Gesellschaft https://doi.org/10.13039/501100004189
Deutsche Forschungsgemeinschaft https://doi.org/10.13039/501100001659
H2020 European Research Council https://doi.org/10.13039/100010663