Bcl-XL increases axonal numbers but not axonal elongation from rat retinal explants
2006 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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- Authors
- Dietz, G. P. H. ; Dietz, B. ; Bähr, M.
- Abstract
- The Bcl-2 family of proteins has been characterized as a key regulator of cell death programs. In addition, these proteins also play important roles in cellular differentiation, such as axonal growth. The role of Bcl-2 family members on axonal regeneration and neurite extension has been controversial so far. Here, we examine the influence of Bcl-x(L) on axonal regeneration from adult retina explants in vitro. We delivered recombinant Bcl-x(L) into retinal tissue, mediated by the Tat-protein transduction domain, and observed its effect on retinal axon extension. We found that Bcl-xL increased the number of regenerating neurites, but did not increase their length. Our results indicate that Bcl-x(L) stimulates axonal initiation but not axonal elongation after crush injury to retinal explants, without altering the number of surviving neurons. (c) 2006 Elsevier Inc. All rights reserved.
- Issue Date
- 2006
- Journal
- Brain Research Bulletin
- ISSN
- 0361-9230
- Language
- English