In situ architecture of neuronal α-Synuclein inclusions

2021-04-14 | journal article; research paper. A publication with affiliation to the University of Göttingen.

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​In situ architecture of neuronal α-Synuclein inclusions​
Trinkaus, V. A.; Riera-Tur, I.; Martínez-Sánchez, A.; Bäuerlein, F. J. B.; Guo, Q.; Arzberger, T. & Baumeister, W. et al.​ (2021) 
Nature Communications, 12(1).​ DOI: https://doi.org/10.1038/s41467-021-22108-0 

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Authors
Trinkaus, Victoria A.; Riera-Tur, Irene; Martínez-Sánchez, Antonio; Bäuerlein, Felix J. B.; Guo, Qiang; Arzberger, Thomas; Baumeister, Wolfgang; Dudanova, Irina; Hipp, Mark S.; Hartl, F. Ulrich; Fernández-Busnadiego, Rubén
Abstract
The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. Here, authors use cryo-electron tomography to image neuronal α-Syn inclusions in situ and find that inclusions consist of α-Syn fibrils intermixed with cellular organelles without interacting directly.
Issue Date
14-April-2021
Journal
Nature Communications 
Project
EXC 2067: Multiscale Bioimaging 
Working Group
RG Fernández-Busnadiego (Structural Cell Biology) 
eISSN
2041-1723
Language
English
Sponsor
EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)) https://doi.org/10.13039/100011199
Deutsche Forschungsgemeinschaft (German Research Foundation) https://doi.org/10.13039/501100001659
Michael J. Fox Foundation for Parkinson’s Research (Michael J. Fox Foundation) https://doi.org/10.13039/100000864

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