Defective COX1 expression in aging mice liver
2023 | journal article. A publication with affiliation to the University of Göttingen.
Jump to: Cite & Linked | Documents & Media | Details | Version history
Documents & Media
Details
- Authors
- Witte, Steffen; Boshnakovska, Angela; Özdemir, Metin; Chowdhury, Arpita; Rehling, Peter ; Aich, Abhishek
- Abstract
- ABSTRACT Mitochondrial defects are associated with aging processes and age-related diseases, including cardiovascular diseases, neurodegenerative diseases and cancer. In addition, some recent studies suggest mild mitochondrial dysfunctions appear to be associated with longer lifespans. In this context, liver tissue is considered to be largely resilient to aging and mitochondrial dysfunction. Yet, in recent years studies report dysregulation of mitochondrial function and nutrient sensing pathways in ageing livers. Therefore, we analyzed the effects of the aging process on mitochondrial gene expression in liver using wildtype C57BL/6N mice. In our analyses, we observed alteration in mitochondrial energy metabolism with age. To assess if defects in mitochondrial gene expression are linked to this decline, we applied a Nanopore sequencing based approach for mitochondrial transcriptomics. Our analyses show that a decrease of the Cox1 transcript correlates with reduced respiratory complex IV activity in older mice livers.
- Issue Date
- 2023
- Journal
- Biology Open
- Project
- SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz
SFB 1002 | A06: Molekulare Grundlagen mitochondrialer Kardiomyopathien
EXC 2067: Multiscale Bioimaging - Working Group
- RG Rehling (Mitochondrial Protein Biogenesis)
- eISSN
- 2046-6390
- Language
- English