Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives
2023 | journal article. A publication with affiliation to the University of Göttingen.
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Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives
Huang, B.; Chau, S. W. H.; Liu, Y.; Chan, J. W. Y.; Wang, J.; Ma, S. L. & Zhang, J. et al. (2023)
Nature Communications, 14(1). DOI: https://doi.org/10.1038/s41467-023-38248-4
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Details
- Authors
- Huang, Bei; Chau, Steven W. H.; Liu, Yaping; Chan, Joey W. Y.; Wang, Jing; Ma, Suk Ling; Zhang, Jihui; Chan, Paul K. S.; Yeoh, Yun Kit; Chen, Zigui; Wing, Yun Kwok
- Abstract
- Abstract The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model of PD. We show gut microbiota compositions are significantly altered in early PD and RBD compared with control and RBD-FDR. Depletion of butyrate-producing bacteria and enrichment of pro-inflammatory Collinsella have already emerged in RBD and RBD-FDR after controlling potential confounders including antidepressants, osmotic laxatives, and bowel movement frequency. Random forest modelling identifies 12 microbial markers that are effective to distinguish RBD from control. These findings suggest that PD-like gut dysbiosis occurs at the prodromal stages of PD when RBD develops and starts to emerge in the younger RBD-FDR subjects. The study will have etiological and diagnostic implications.
- Issue Date
- 2023
- Journal
- Nature Communications
- eISSN
- 2041-1723
- Language
- English
- Sponsor
- Food and Health Bureau of the Government of the Hong Kong Special Administrative Region | Health and Medical Research Fund https://doi.org/10.13039/501100005847
Research Grants Council, University Grants Committee https://doi.org/10.13039/501100002920
Centre for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong (CUHK), Hong Kong