Reactions in Endohedral Functionalized Cages

Abstract

The introduction of enhanced functionalization is a key aspect in the current design of cage chemistry. At the moment, several approaches are intensively investigated. The synthesis of cage compounds that display endohedral functionalization plays a key role among them. Here, the studies of reactions that occur in endohedral-functionalized cage compounds is reviewed. After an introduction in current trends in cage-chemistry the discussion of reactions in endohedral-cage compounds is divided into three sections. These are: 1) Endohedral groups that are by themselves functional, 2) endohedral groups that can bind to a transition-metal complex and 3) endohedral groups that can bind by themselves to a metal. The article closes with an outlook on additional current developments in the field of endohedral-functionalized cage-compounds, which may contribute in the future towards reactivity in cage compounds.

<p xmlns:mml="http://www.w3.org/1998/Math/MathML" xml:lang="en">Endohedral‐functionalized cage compounds play an increasing role in cage chemistry. Here, the recent developments of reactions that are mediated or catalyzed by such endohedral‐functionalized cages is reviewed. The article is structured according to the role that the endohedral group plays with respect to the reaction mediated or catalyzed.<boxed-text position="anchor" content-type="graphic" xml:lang="en"> <graphic position="anchor" id="jats-graphic-1" xlink:href="urn:x-wiley:1434193X:media:ejoc202300012:ejoc202300012-toc-0001"> <alt-text>image</alt-text> </graphic></boxed-text> </p>