Towards semisynthetic natural compounds with a biaryl axis: Oxidative phenol coupling in Aspergillus niger
2018-04-01 | journal article
Jump to: Cite & Linked | Documents & Media | Details | Version history
Documents & Media
Details
- Authors
- Hugentobler, Katharina Gloria ; Müller, Michael
- Abstract
- Regio- and stereoselective phenol coupling is difficult to achieve using synthetic strategies. However, in nature, cytochrome P450 enzyme-mediated routes are employed to achieve complete axial stereo- and regiocontrol in the biosynthesis of compounds with potent bioactivity. Here, we report a synthetic biology approach whereby the bicoumarin metabolic pathway in Aspergillus niger was specifically tailored towards the formation of new coupling products. This strategy represents a manipulation of the bicoumarin pathway in A. niger via interchange of the phenol-coupling biocatalyst and could be applied to other components of the pathway to access a variety of atropisomeric natural product derivatives.
- Issue Date
- 1-April-2018
- Journal
- Bioorganic & Medicinal Chemistry
- ISSN
- 0968-0896
- eISSN
- 1464-3391
- Language
- English