Residual‐Chemical‐Shift‐Anisotropy‐Based Enantiodifferentiation in Lyotropic Liquid Crystalline Phases Based on Helically Chiral Polyacetylenes
2023 | journal article. A publication with affiliation to the University of Göttingen.
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Residual‐Chemical‐Shift‐Anisotropy‐Based Enantiodifferentiation in Lyotropic Liquid Crystalline Phases Based on Helically Chiral Polyacetylenes
Fuentes-Monteverde, J. C.; Noll, M.; Das, A.; Immel, S.; Reggelin, M.; Nath, N. & Griesinger, C. (2023)
Angewandte Chemie International Edition, art. e202309981. DOI: https://doi.org/10.1002/anie.202309981
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- Authors
- Fuentes-Monteverde, Juan Carlos; Noll, Markus; Das, Akhi; Immel, Stefan; Reggelin, Michael; Nath, Nilamoni; Griesinger, Christian
- Abstract
- Anisotropic NMR spectroscopy, revealing residual dipolar couplings (RDCs) and residual chemical shift anisotropies (RCSAs) has emerged as a powerful tool to determine the configurations of synthetic and complex natural compounds. The deduction of the absolute in addition to the relative configuration is one of the primary goals in the field. Therefore, the investigation of the enantiodiscriminating capabilities of chiral alignment media becomes essential. While RDCs and RCSAs are used for the determination of the relative configuration now routinely, RCSAs have not been measured in chiral alignment media such as chiral liquid crystals. Herein, we present this application by measuring RCSAs for chiral analytes such as indanol and isopinocampheol in the lyotropic liquid crystalline phase of an L‐valine derived helically chiral polyacetylenes. We have also demonstrated that a single 1D 13C‐{1H} NMR spectrum suffices to get the RCSAs circumventing the necessity to acquire two spectra at two alignment conditions.
- Issue Date
- 2023
- Journal
- Angewandte Chemie International Edition
- ISSN
- 1433-7851
- eISSN
- 1521-3773
- Language
- English