A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
2020 | journal article. A publication with affiliation to the University of Göttingen.
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A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
Shen, X.; Howard, D. M.; Adams, M. J.; Hill, W. D.; Clarke, T.-K.; Adams, M. J. & Clarke, T.-K. et al. (2020)
Nature Communications, 11(1). DOI: https://doi.org/10.1038/s41467-020-16022-0
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- Authors Group
- Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
The authors list is uncomplete: - Authors
- Shen, Xueyi; Howard, David M.; Adams, Mark J.; Hill, W. David; Clarke, Toni-Kim; Adams, Mark J.; Clarke, Toni-Kim; McIntosh, Andrew M.; Deary, Ian J.; Wray, Naomi R.; McIntosh, Andrew M.
- Abstract
- Abstract Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery ( N = 10,674) and replication ( N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to depression on brain white matter microstructure ( β : 0.125 to 0.868, p FDR < 0.043). Several behavioural traits are also associated with depression-PRS ( β : 0.014 to 0.180, p FDR : 0.049 to 1.28 × 10 −14 ) and we find a significant and positive interaction between depression-PRS and adverse environmental exposures on mental health outcomes. This study reveals replicable associations between depression-PRS and white matter microstructure. Our results indicate that white matter microstructure differences may be a causal consequence of liability to depression.
- Issue Date
- 2020
- Journal
- Nature Communications
- eISSN
- 2041-1723
- Language
- English
- Sponsor
- China Scholarship Council https://doi.org/10.13039/501100004543
University of Edinburgh https://doi.org/10.13039/501100000848
Wellcome Trust https://doi.org/10.13039/100004440