High dose vitamin D exacerbates central nervous system autoimmunity by raising T-cell excitatory calcium
2019 | journal article. A publication with affiliation to the University of Göttingen.
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High dose vitamin D exacerbates central nervous system autoimmunity by raising T-cell excitatory calcium
Häusler, D.; Torke, S.; Peelen, E.; Bertsch, T.; Djukic, M.; Nau, R. & Larochelle, C. et al. (2019)
Brain, 142(9) pp. 2737-2755. DOI: https://doi.org/10.1093/brain/awz190
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Details
- Authors
- Häusler, Darius; Torke, Sebastian; Peelen, Evelyn; Bertsch, Thomas; Djukic, Marija; Nau, Roland; Larochelle, Catherine; Zamvil, Scott S; Brück, Wolfgang; Weber, Martin S
- Abstract
- Patients with multiple sclerosis are often given vitamin D supplements. However, Häusler, Torke et al. show an unexpected exacerbation of experimental autoimmune encephalomyelitis in mice given high but not moderate doses of supplementary vitamin D. Continuous high-dose vitamin D caused secondary hypercalcaemia, which promoted pro-inflammatory T-cell responses.
- Issue Date
- 2019
- Journal
- Brain
- ISSN
- 0006-8950
- eISSN
- 1460-2156
- Language
- English
