Enantioselective Cobalt(III)‐Catalyzed C−H Activation Enabled by Chiral Carboxylic Acid Cooperation
2018 | journal article. A publication with affiliation to the University of Göttingen.
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Enantioselective Cobalt(III)‐Catalyzed C−H Activation Enabled by Chiral Carboxylic Acid Cooperation
Pesciaioli, F.; Dhawa, U.; Oliveira, J. C. A.; Yin, R.; John, M. & Ackermann, L. (2018)
Angewandte Chemie International Edition, 57(47) pp. 15425-15429. DOI: https://doi.org/10.1002/anie.201808595
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Details
- Authors
- Pesciaioli, Fabio; Dhawa, Uttam; Oliveira, João C. A.; Yin, Rongxin; John, Michael; Ackermann, Lutz
- Abstract
- Abstract The enantioselective cobalt(III)‐catalyzed C−H alkylation was achieved through the design of a novel chiral acid. The cobalt(III)‐catalyzed enantioselective C−H activation was characterized by high position‐, regio‐ and enantio‐control under exceedingly mild reaction conditions. Thereby, the robust cooperative cobalt(III) catalysis proved tolerant of valuable electrophilic functional groups, including hydroxyl, bromo, and iodo substituents. Mechanistic studies revealed a considerable additive effect on kinetics and on a negative non‐linear‐effect.
- Issue Date
- 2018
- Journal
- Angewandte Chemie International Edition
- ISSN
- 1433-7851
- eISSN
- 1521-3773
- Language
- English
- Sponsor
- Deutsche Forschungsgemeinschaft https://doi.org/10.13039/501100001659
Deutscher Akademischer Austauschdienst https://doi.org/10.13039/501100001655
Fondazione Cariplo https://doi.org/10.13039/501100002803
