Gold‐Catalyzed Atroposelective Synthesis of 1,1′‐Binaphthalene‐2,3′‐diols
2020 | journal article. A publication with affiliation to the University of Göttingen.
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Gold‐Catalyzed Atroposelective Synthesis of 1,1′‐Binaphthalene‐2,3′‐diols
Zhang, J.; Simon, M.; Golz, C. & Alcarazo, M. (2020)
Angewandte Chemie International Edition, 59(14) pp. 5647-5650. DOI: https://doi.org/10.1002/anie.201915456
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Details
- Authors
- Zhang, Jianwei; Simon, Martin; Golz, Christopher; Alcarazo, Manuel
- Abstract
- Abstract A highly atroposelective (up to 97 % ee ) Au‐catalyzed synthesis of 1,1′‐binaphthalene‐2,3′‐diols is reported starting from a range of substituted benzyl alkynones. Essential for the achievement of high enantioselectivity during the key assembly of the naphto‐3‐ol unit is the use of TADDOL‐derived α‐cationic phosphonites as ancillary ligands. Preliminary results demonstrate that the transformation of the obtained binaphthyls into axially chiral monodentate phosphines is possible without degradation of enantiopurity.
- Issue Date
- 2020
- Journal
- Angewandte Chemie International Edition
- ISSN
- 1433-7851
- eISSN
- 1521-3773
- Language
- English
- Sponsor
- Deutsche Forschungsgemeinschaft https://doi.org/10.13039/501100001659
