Implications for neutrophils in cardiac arrhythmias
2023 | journal article; overview. A publication with affiliation to the University of Göttingen.
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Implications for neutrophils in cardiac arrhythmias
Hegemann, N.; Barth, L.; Doering, Y.; Voigt, N. & Grune, J. (2023)
American Journal of Physiology-Heart and Circulatory Physiology, art. ajpheart.00590.2023. DOI: https://doi.org/10.1152/ajpheart.00590.2023
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Details
- Authors
- Hegemann, Niklas; Barth, Lukas; Doering, Yannic; Voigt, Niels; Grune, Jana
- Abstract
- Cardiac arrhythmias commonly occur as a result of aberrant electrical impulse formation or conduction in the myocardium. Frequently discussed triggers include underlying heart diseases such as myocardial ischemia, electrolyte imbalances or genetic anomalies of ion channels involved in the tightly regulated cardiac action potential. Recently, the role of innate immune cells in the onset of arrhythmic events has been highlighted in numerous studies, correlating leukocyte expansion in the myocardium to increased arrhythmic burden. Here, we aim to call attention to the role of neutrophils in the pathogenesis of cardiac arrhythmias and their expansion during myocardial ischemia and infectious disease manifestation. In addition, we will elucidate molecular mechanisms associated with neutrophil activation and discuss their involvement as key, direct mediators of arrhythmogenicity.
- Issue Date
- 2023
- Journal
- American Journal of Physiology-Heart and Circulatory Physiology
- Project
- EXC 2067: Multiscale Bioimaging
SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz
SFB 1002 | A13: Bedeutung einer gestörten zytosolischen Calciumpufferung bei der atrialen Arrhythmogenese bei Patienten mit Herzinsuffizienz (HF) - Working Group
- RG Voigt (Molecular Pharmacology)
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Language
- English
- Sponsor
- Deutsches Zentrum für Herz-Kreislaufforschung 10.13039/100010447
Deutsche Forschungsgemeinschaft 10.13039/501100001659
Freie Universität Berlin 10.13039/501100007537
Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung. 10.13039/501100010578
Corona-Stiftung 10.13039/100016021
Deutsche Stiftung für Herzforschung 10.13039/501100005970
Charité – Universitätsmedizin Berlin 10.13039/501100002839
Deutsche Forschungsgemeinschaft 10.13039/501100001659
Deutsches Zentrum für Herz-Kreislaufforschung 10.13039/100010447