Characteristics, Prevalence, and Clinical Relevance of Juxtacortical Paramagnetic Rims in Patients With Multiple Sclerosis
2024-02-13 | journal article
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Characteristics, Prevalence, and Clinical Relevance of Juxtacortical Paramagnetic Rims in Patients With Multiple Sclerosis
Galbusera, R.; Bahn, E.; Weigel, M.; Cagol, A.; Lu, P.-J.; Schaedelin, S. A. & Franz, J. et al. (2024)
Neurology, 102(3) art. e207966. DOI: https://doi.org/10.1212/WNL.0000000000207966
Documents & Media
Details
- Authors
- Galbusera, Riccardo; Bahn, Erik; Weigel, Matthias; Cagol, Alessandro; Lu, Po-Jui; Schaedelin, Sabine A.; Franz, Jonas; Barakovic, Muhamed; Rahmanzadeh, Reza; Dechent, Peter; Nair, Govind; Brück, Wolfgang; Kuhle, Jens; Kappos, Ludwig; Stadelmann, Christine; Granziera, Cristina
- Abstract
- A subgroup of patients with multiple sclerosis (MS) presents focal paramagnetic rims at the border between cortex and white matter (juxtacortical paramagnetic rims [JPRs]). We investigated the presence of this finding in our in vivo MS cohort and explored its potential clinical relevance. Moreover, we exploited postmortem MRI of fixed whole MS brains to (1) detect those rims and (2) investigate their histologic correlation.
- Issue Date
- 13-February-2024
- Journal
- Neurology
- Project
- EXC 2067: Multiscale Bioimaging
TRR 274: Checkpoints of Central Nervous System Recovery
TRR 274 | B01: The role of inflammatory cytokine signaling for efficient remyelination in multiple sclerosis - Working Group
- RG Stadelmann-Nessler
RG Brück - ISSN
- 0028-3878
- eISSN
- 1526-632X
- Language
- English
