Validating a minipig model of reversible cerebral demyelination using human diagnostic modalities and electron microscopy
2024-02 | journal article. A publication with affiliation to the University of Göttingen.
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Validating a minipig model of reversible cerebral demyelination using human diagnostic modalities and electron microscopy
Ancău, M.; Tanti, G. K.; Butenschoen, V. M.; Gempt, J.; Yakushev, I.; Nekolla, S. & Mühlau, M. et al. (2024)
EBioMedicine, 100 art. 104982. DOI: https://doi.org/10.1016/j.ebiom.2024.104982
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Details
- Authors
- Ancău, Mihai; Tanti, Goutam Kumar; Butenschoen, Vicki Marie; Gempt, Jens; Yakushev, Igor; Nekolla, Stephan; Mühlau, Mark; Scheunemann, Christian; Heininger, Sebastian; Löwe, Benjamin; Löwe, Erik; Baer, Silke; Fischer, Johannes; Reiser, Judith; Ayachit, Sai S; Liesche-Starnecker, Friederike; Schlegel, Jürgen; Matiasek, Kaspar; Schifferer, Martina; Kirschke, Jan S; Misgeld, Thomas; Lueth, Tim; Hemmer, Bernhard
- Abstract
- Inflammatory demyelinating diseases of the central nervous system, such as multiple sclerosis, are significant sources of morbidity in young adults despite therapeutic advances. Current murine models of remyelination have limited applicability due to the low white matter content of their brains, which restricts the spatial resolution of diagnostic imaging. Large animal models might be more suitable but pose significant technological, ethical and logistical challenges.
- Issue Date
- February-2024
- Journal
- EBioMedicine
- Project
- TRR 274: Checkpoints of Central Nervous System Recovery
TRR 274 | B03: Checkpoints of recovery after primary astrocytic lesions in neuromyelitis optica and related animal models
TRR 274 | Z01: Bioimaging Platform - Working Group
- RG Misgeld
RG Schifferer - eISSN
- 2352-3964
- Language
- English
