Influence of TGF-β1 on tumor transition in oral cancer cell and BMSC co-cultures
2017-05 | journal article
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Influence of TGF-β1 on tumor transition in oral cancer cell and BMSC co-cultures
Böhrnsen, F. ; Godek, F. ; Kiesel, J. ; Kramer, F.-J. ; Brockmeyer, P. & Schliephake, H. (2017)
Journal of Cranio-Maxillofacial Surgery, 45(5) pp. 731-740. DOI: https://doi.org/10.1016/j.jcms.2017.02.009
Documents & Media
Details
- Authors
- Böhrnsen, Florian ; Godek, F. ; Kiesel, J. ; Kramer, Franz-Josef ; Brockmeyer, Phillipp ; Schliephake, Henning
- Abstract
- TGF-β1 signaling modulates epithelial mesenchymal transitions (EMT) of head and neck squamous cell carcinoma (HNSCC). Bone marrow mesenchymal stromal cells (BMSC) are able to exert a regulating influence on the expression of markers of EMT in HNSCC cells. It was thus the aim of this study to test the hypothesis that TGF-β1 modulates the interactions of tumor transition between BMSCs and HNSCC, affecting the expression of E-cadherin, Vimentin, Snail, Twist, MMP14 and beta-catenin. Furthermore, we analyzed alterations in the AKT-signaling of tumor and stroma cells.
- Issue Date
- May-2017
- Journal
- Journal of Cranio-Maxillofacial Surgery
- eISSN
- 1878-4119
- Language
- English
