Bone Morphogenetic Protein-2 Hybridized with Nano-Anchored Oligonucleotides on Titanium Implants Enhances Osteogenic Differentiation In Vivo
2017 | journal article
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Bone Morphogenetic Protein-2 Hybridized with Nano-Anchored Oligonucleotides on Titanium Implants Enhances Osteogenic Differentiation In Vivo
Böhrnsen, F. ; Rublack, J. ; Aeckerle, N. ; Foerster, A.; Schwenzer, B.; Reichert, J. & Scharnweber, D. et al. (2017)
The International Journal of Oral and Maxillofacial Implants, 32(3) pp. e175-e182. DOI: https://doi.org/10.11607/jomi.5256
Documents & Media
Details
- Authors
- Böhrnsen, Florian ; Rublack, Jennifer ; Aeckerle, Nelia ; Foerster, Anne; Schwenzer, Bernd; Reichert, Judith; Scharnweber, Dieter; Schliephake, Henning
- Abstract
- Previous in vitro studies have shown that DNA oligonucleotides (ODN) can be successfully used as anchor strands for the binding and retarded release of biologically active recombinant human bone morphogenetic protein 2 (rhBMP-2). The aim of the present study was to test the hypothesis that rhBMP-2 bound to the surface of titanium implants through hybridization with nano-anchored ODN strands is biologically active and can enhance the induction of osteogenic markers in peri-implant bone in vivo.
- Issue Date
- 2017
- Journal
- The International Journal of Oral and Maxillofacial Implants
- eISSN
- 1942-4434
- Language
- English
