Palladium-Catalyzed 4-Fold Domino Reaction for the Synthesis of a Polymeric Double Switch

Abstract

A palladium-catalyzed 4-fold domino reaction consisting of two carbopalladation reactions and two C–H activation reactions, followed by the introduction of an acrylate moiety, led to the tetra-substituted helical alkene A2, using the dialkyne A3 as a substrate. The alkene was copolymerized with butyl acrylate by using the reversible addition–fragmentation chain transfer polymerization (RAFT) to give the desired polymeric switch A1.