Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals
2004 | review. A publication with affiliation to the University of Göttingen.
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- Authors
- Brose, Nils ; Betz, Andrea ; Wegmeyer, Heike
- Abstract
- Diacylglycerol is an essential second messenger in mammalian cells. The most prominent intracellular targets of diacylglycerol and the functionally analogous phorbol esters belong to the protein kinase C family, but at least five alternative types of high affinity diacylglycerol/phorbol ester receptors are known: protein kinase D, diacylglycerol kinases alpha, beta, and gamma, RasGRPs, chimaerins, and Munc13s. These function independently of protein kinase C isozymes, and form a network of signaling pathways in the diacylglycerol second messenger system that regulates processes as diverse as gene transcription, lipid signaling, cytoskeletal dynamics, intracellular membrane trafficking, or neurotransmitter release.
- Issue Date
- 2004
- Publisher
- Current Biology Ltd
- Journal
- Current Opinion in Neurobiology
- ISSN
- 0959-4388