68Ga-Pentixafor PET/CT Imaging of Chemokine Receptor CXCR4 in Chronic Infection of the Bone: First Insights
2018-02 | journal article. A publication with affiliation to the University of Göttingen.
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68Ga-Pentixafor PET/CT Imaging of Chemokine Receptor CXCR4 in Chronic Infection of the Bone: First Insights
Bouter, C. ; Meller, B. ; Sahlmann, C. O ; Staab, W. ; Wester, H.-J.; Kropf, S. & Meller, J. (2018)
Journal of Nuclear Medicine, 59(2) pp. 320-326. DOI: https://doi.org/10.2967/jnumed.117.193854
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- Authors
- Bouter, Caroline ; Meller, Birgit ; Sahlmann, Carsten O ; Staab, Wieland ; Wester, Hans-Juergen; Kropf, Saskia; Meller, Johannes
- Abstract
- Because of its role in infection and inflammatory processes, the chemokine receptor CXCR4 might be a potent target in imaging of infectious and inflammatory diseases. The aim of this pilot study was to determine whether the CXCR4 ligand 68Ga-pentixafor is suitable for imaging chronic infection of the bone. Methods: The study comprised 14 patients with suspected infection of the skeleton who underwent 68Ga-pentixafor PET/CT between April 2015 and February 2017 in our facility. 68Ga-pentixafor PET/CT results were retrospectively evaluated against a histologic, bacteriologic, and clinical standard. The results were also compared with available bone scintigraphy, white blood cell scintigraphy, and 18F-FDG PET/CT results. Results:68Ga-pentixafor PET/CT was positive in 9 of 14 patients. Diagnoses included osteitis or osteomyelitis of peripheral bone, osteomyelitis of the maxilla, and infected endoprostheses. Target-to-background ratios were 5.1-15 (mean, 8.7). Eight of 9 cases were true-positive as confirmed by pathology, bacteriology, or clinical observation. All negative cases were confirmed as true-negative by other imaging modalities and follow-up. Conclusion: Imaging of CXCR4 expression with 68Ga-pentixafor PET/CT appears suitable for diagnosing chronic infection of the skeleton. The findings of this study reveal a possible diagnostic gain in suspected chronic infections that are difficult to diagnose by other imaging modalities.
- Issue Date
- February-2018
- Journal
- Journal of Nuclear Medicine
- Organization
- Klinik für Nuklearmedizin
- eISSN
- 1535-5667
- Language
- English