Molecular Changes in White Matter Adjacent to an Active Demyelinating Lesion in Early Multiple Sclerosis
2009 | journal article. A publication with affiliation to the University of Göttingen.
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Molecular Changes in White Matter Adjacent to an Active Demyelinating Lesion in Early Multiple Sclerosis
Zeis, T.; Probst, A.; Steck, A. J.; Stadelmann, C. ; Brueck, W. & Schaeren-Wiemers, N. (2009)
Brain Pathology, 19(3) pp. 459-466. DOI: https://doi.org/10.1111/j.1750-3639.2008.00231.x
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- Authors
- Zeis, Thomas; Probst, Alfonse; Steck, Andreas Johann; Stadelmann, Christine ; Brueck, Wolfgang; Schaeren-Wiemers, Nicole
- Abstract
- A stereotactic biopsy of a 17-year-old woman revealed an active inflammatory demyelinating lesion compatible with pattern III multiple sclerosis (MS) according to Lucchinetti et al. The biopsy included a white matter region distant from the active inflammatory demyelinating lesion with abnormal MRI signal, lacking histopathological signs of demyelination and/or oligodendrocyte apoptosis. Expression analysis of this area revealed a strong up-regulation of neuronal nitric oxide synthase (nNOS). Furthermore, detection of nitrotyrosine provided evidence for reactive nitrogen species (RNS)-mediated damage to oligodendrocytes. Concomitantly, genes involved in neuroprotection against oxidative stress such as heme oxygenase 1 were up-regulated. Even though a single case report, this study shows earliest molecular changes in white matter surrounding an actively demyelinating lesion during the first manifestation of MS, pointing toward a more widespread pathological process. Therapeutic targeting of the identified mechanisms of tissue injury might be crucial to prevent further lesion formation or secondary tissue damage.
- Issue Date
- 2009
- Status
- published
- Publisher
- Wiley-blackwell Publishing, Inc
- Journal
- Brain Pathology
- ISSN
- 1015-6305