Myelinopathia centralis diffusa (vanishing white matter disease): Evidence of apoptotic oligodendrocyte degeneration in early lesion development
2001 | journal article. A publication with affiliation to the University of Göttingen.
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Myelinopathia centralis diffusa (vanishing white matter disease): Evidence of apoptotic oligodendrocyte degeneration in early lesion development
Bruck, W. W.; Herms, J.; Brockmann, K.; Schulz-Schaeffer, W. J. & Hanefeld, F. (2001)
Annals of Neurology, 50(4) pp. 532-536. DOI: https://doi.org/10.1002/ana.1227
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Details
- Authors
- Bruck, Wolfgang W.; Herms, J.; Brockmann, Knut; Schulz-Schaeffer, Walter J.; Hanefeld, Folker
- Abstract
- We describe histopathological changes in a 2-year-old boy who died from myelinopathia centralis diffusa. Despite extensive white matter destruction, surprisingly high numbers of oligodendrocytes expressing proteolipid protein mRNA were detected. In an active demyelinating lesion in the brainstem, oligodendrocytes showed typical signs of apoptosis. We suggest that death of mature oligodendrocytes is the critical event in the disease.
- Issue Date
- 2001
- Status
- published
- Publisher
- Wiley-liss
- Journal
- Annals of Neurology
- ISSN
- 0364-5134
