Preclinical Deposition of Pathological Prion Protein in Muscle of Experimentally Infected Primates
2010 | journal article. A publication with affiliation to the University of Göttingen.
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Preclinical Deposition of Pathological Prion Protein in Muscle of Experimentally Infected Primates
Krasemann, S.; Neumann, M.; Geissen, M.; Bodemer, W. ; Kaup, F.-J.; Schulz-Schaeffer, W. J. & Morel, N. et al. (2010)
PLoS ONE, 5(11) art. e13906. DOI: https://doi.org/10.1371/journal.pone.0013906
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Details
- Authors
- Krasemann, Susanne; Neumann, Melanie; Geissen, Markus; Bodemer, Walter ; Kaup, Franz-Josef; Schulz-Schaeffer, Walter J.; Morel, Nathalie; Aguzzi, Adriano; Glatzel, Markus
- Abstract
- Prion diseases are transmissible fatal neurodegenerative disorders affecting humans and animals. A central step in disease progression is the accumulation of a misfolded form (PrPSc) of the host encoded prion protein (PrPC) in neuronal and non-neuronal tissues. The involvement of peripheral tissues in preclinical states increases the risk of accidental transmission. On the other hand, detection of PrPSc in non-neuronal easy-accessible compartments such as muscle may offer a novel diagnostic tool. Primate models have proven invaluable to investigate prion diseases. We have studied the deposition of PrPSc in muscle and central nervous system of rhesus monkeys challenged with sporadic Creutzfeldt-Jakob disease (sCJD), variant CJD (vCJD) and bovine spongiform encephalopathy (BSE) in preclinical and clinical stage using biochemical and morphological methods. Here, we show the preclinical presence of PrPSc in muscle and central nervous system of rhesus monkeys experimentally infected with vCJD.
- Issue Date
- 2010
- Status
- published
- Publisher
- Public Library Science
- Journal
- PLoS ONE
- ISSN
- 1932-6203