The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: Findings from a large German case-control and family-based sample
2010 | journal article. A publication with affiliation to the University of Göttingen.
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The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: Findings from a large German case-control and family-based sample
Nieratschker, V.; Frank, J.; Muehleisen, T. W.; Strohmaier, J.; Wendland, J. R.; Schumacher, J. & Treutlein, J. et al. (2010)
Schizophrenia Research, 122(1-3) pp. 24-30. DOI: https://doi.org/10.1016/j.schres.2010.06.018
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Details
- Authors
- Nieratschker, Vanessa; Frank, Josef; Muehleisen, Thomas W.; Strohmaier, Jana; Wendland, Jens R.; Schumacher, Johannes; Treutlein, Jens; Breuer, Rene; Abou Jamra, Rami; Mattheisen, Manuel; Herms, Stefan; Schmael, Christine; Maier, Wolfgang; Noethen, Markus M.; Cichon, Sven; Rietschel, Marcella; Schulze, Thomas G.
- Abstract
- The aim of the present study was to investigate possible associations between schizophrenia and 13 SNP markers in COMT. No association was observed in 631 cases, 207 nuclear families, and 776 controls. A cognitive performance phenotype (Trail Marking Test) was available for a subgroup of the patients. No association was found between the 13 markers and this phenotype. Four clinically-defined subgroups (early age at onset, negative symptoms, family history of schizophrenia, and life-time major depressive episode) were also investigated. Associations were observed for 3 of these subgroups, although none withstood correction for multiple testing. COMT does not appear to be a risk factor for schizophrenia in this population. (C) 2010 Elsevier B.V. All rights reserved.
- Issue Date
- 2010
- Status
- published
- Publisher
- Elsevier Science Bv
- Journal
- Schizophrenia Research
- ISSN
- 0920-9964
