Complexins regulate a late step in Ca²⁺-dependent neurotransmitter release
2001 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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- Authors
- Reim, Kerstin; Mansour, M.; Varoqueaux, Frederique; McMahon, H. T.; Südhof, T. C.; Brose, N. ; Rosenmund, C.
- Abstract
- Synaptic vesicle fusion at synapses is triggered by increases in cytosolic Ca²⁺ levels. However, the identity of the Ca²⁺ sensor and the transduction mechanism of the Ca²⁺ trigger are unknown. We show that Complexins, stoichiometric components of the exocytotic core complex, are important regulators of transmitter release at a step immediately preceding vesicle fusion. Neurons lacking Complexins show a dramatically reduced transmitter release efficiency due to decreased Ca²⁺ sensitivity of the synaptic secretion process. Analyses of mutant neurons demonstrate that Complexins are acting at or following the Ca²⁺-triggering step of fast synchronous transmitter release by regulating the exocytotic Ca²⁺ sensor, its interaction with the core complex fusion machinery, or the efficiency of the fusion apparatus itself.
- Issue Date
- 2001
- Journal
- Cell
- ISSN
- 0092-8674