Differential Pattern of Brain-Specific CSF Proteins Tau and Amyloid-Beta in Parkinsonian Syndromes
2010 | journal article. A publication with affiliation to the University of Göttingen.
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Differential Pattern of Brain-Specific CSF Proteins Tau and Amyloid-Beta in Parkinsonian Syndromes
Suessmuth, S. D.; Uttner, I.; Landwehrmeyer, B.; Pinkhardt, E. H.; Brettschneider, J.; Petzold, A. & Kramer, B. et al. (2010)
Movement Disorders, 25(9) pp. 1284-1288. DOI: https://doi.org/10.1002/mds.22895
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Details
- Authors
- Suessmuth, Sigurd D.; Uttner, Ingo; Landwehrmeyer, Bernhard; Pinkhardt, Elmar H.; Brettschneider, Johannes; Petzold, Axel; Kramer, Bernd; Schulz, Joerg B.; Palm, Christian; Otto, Markus; Ludolph, Albert C.; Kassubek, Jan; Tumani, Hayrettin
- Abstract
- To evaluate cerebrospinal fluid (CSF) proteins reflecting processes of neurodegeneration and glial activation in progressive supranuclear palsy (PSP; Richardson's syndrome, n = 20; PSP-Parkinsonism, n = 7) and multiple system atrophy (MSA, n = 25), we analyzed tau, phosphorylated tau, amyloid-beta(1-42) (A beta 1-42), A beta 1-40, glial fibrillary acidic protein (GFAP), and CSF routine variables. Individuals with PSP-Parkinsonism and MSA had elevated tau levels when compared with Richardson's syndrome, Parkinson's disease (PD), and age-matched controls (P <= 0.001). Ratios of P-tau/T-tau were significantly different in Parkinsonian syndromes. CSF A beta 1-42 was decreased only in patients with Richardson's syndrome. In a subset of Parkinsonian syndromes, we found elevated GFAP concentrations and increased CSF/serum albumin ratios. There were no correlations between biomarker concentrations and clinical scores in any of the diseases. In conclusion, this preliminary data show that changes in CSF tau and A beta 1-42 may indicate different protein processing in PSP patients and might, therefore, be relevant in the differentiation of PSP subtypes. (C) 2010 Movement Disorder Society
- Issue Date
- 2010
- Status
- published
- Publisher
- Wiley-liss
- Journal
- Movement Disorders
- ISSN
- 0885-3185