Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release
1998 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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- Authors
- Betz, Andrea ; Ashery, Uri; Rickmann, Michael ; Augustin, Iris; Neher, Erwin ; Südhof, Thomas C.; Rettig, Jens; Brose, Nils
- Abstract
- Munc13-1, a mammalian homolog of C. elegans unc-13p, is thought to be involved in the regulation of synaptic transmission. We now demonstrate that Munc13-1 is a presynaptic high-affinity phorbol ester and diacylglycerol receptor with ligand affinities similar to those of protein kinase C. Munc13-1 associates with the plasma membrane in response to phorbol ester binding and acts as a phorbol ester-dependent enhancer of transmitter release when overexpressed presynaptically in the Xenopus neuromuscular junction. These observations establish Munc13-1 as a novel presynaptic target of the diacylglycerol second messenger pathway that acts in parallel with protein kinase C to regulate neurotransmitter secretion.
- Issue Date
- 1998
- Publisher
- Cell Press
- Journal
- Neuron
- ISSN
- 0896-6273
- eISSN
- 1097-4199