Effect of Cavtratin, a Caveolin-1 Scaffolding Domain Peptide, on Oligodendroglial Signaling Cascades
2011 | journal article. A publication with affiliation to the University of Göttingen.
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Effect of Cavtratin, a Caveolin-1 Scaffolding Domain Peptide, on Oligodendroglial Signaling Cascades
Schmitz, M.; Zerr, I. & Althaus, H. H. (2011)
Cellular and Molecular Neurobiology, 31(7) pp. 991-997. DOI: https://doi.org/10.1007/s10571-011-9694-1
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Details
- Authors
- Schmitz, Matthias; Zerr, Inga; Althaus, Hans H.
- Abstract
- Caveolin and caveolin containing rafts are involved in the signaling of growth factors in various cell types. Previous reports of our lab indicated a co-localization of caveolin and the high affinity nerve growth factor (NGF) receptor tyrosine kinase A (TrkA). Mutual effects have been observed among which a caveolin-1 knock-down resulted in an impairment of the NGF signaling cascade rather than in an increase of activity as expected from other growth factor reports. On the other hand, an over-expression of caveolin-1 impaired the NGF stimulated activity of p42/44 mitogen activated protein kinases (MAPK). In this study, we used a caveolin-1 scaffolding domain (CSD) peptide (cavtratin) of which an inhibitory effect on growth factor receptors was reported. Our data showed that cavtratin suppresses the NGF-induced phosphorylation of TrkA as well as the activation of MAPK in porcine oligodendrocytes significantly.
- Issue Date
- 2011
- Status
- published
- Publisher
- Springer
- Journal
- Cellular and Molecular Neurobiology
- ISSN
- 1573-6830; 0272-4340