TGF-beta and RPE-derived cells in taut subretinal strands from patients with proliferative vitreoretinopathy
2011 | journal article. A publication with affiliation to the University of Göttingen.
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TGF-beta and RPE-derived cells in taut subretinal strands from patients with proliferative vitreoretinopathy
Winkler, J. & Hoerauf, H. (2011)
European Journal of Ophthalmology, 21(4) pp. 422-426. DOI: https://doi.org/10.5301/EJO.2010.6067
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- Authors
- Winkler, Joerg; Hoerauf, Hans
- Abstract
- PURPOSE. To investigate the distribution of transforming growth factor-beta (TGF-beta) and cells derived from the retinal pigment epithelium (RPE) as a major source for TGF-beta in subretinal strands (SRSs), originating from patients with proliferative vitreoretinopathy (PVR) and proliferative diabetic vitreoretinopathy (PDVR). METHODS. Nine SRSs (PVR: n = 6 and PDVR: n = 3) were obtained during pars plana vitrectomy. Specimens were processed for immunohistochemical analysis in paraffin wax or studied by transmission electron microscopy RESULTS. Staining for TGF-beta was consistent in all specimens. The content of RPE-derived cells identified by anticytokeratin staining revealed considerable differences, ranging from < 10 to >> 90%. CONCLUSIONS. The widespread immunoreactivity for TGF-beta in SRSs suggests a significant role of this group of cytokines in the pathologic course of PVR.
- Issue Date
- 2011
- Status
- published
- Publisher
- Wichtig Editore
- Journal
- European Journal of Ophthalmology
- ISSN
- 1120-6721