CoMet-a web server for comparative functional profiling of metagenomes
2011 | journal article. A publication with affiliation to the University of Göttingen.
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- Authors
- Lingner, Thomas; Asshauer, Kathrin Petra; Schreiber, Fabian; Meinicke, Peter
- Abstract
- Analyzing the functional potential of newly sequenced genomes and metagenomes has become a common task in biomedical and biological research. With the advent of high-throughput sequencing technologies comparative metagenomics opens the way to elucidate the genetically determined similarities and differences of complex microbial communities. We developed the web server 'CoMet' (http://comet.gobics.de), which provides an easy-to-use comparative metagenomics platform that is well-suitable for the analysis of large collections of metagenomic short read data. CoMet combines the ORF finding and subsequent assignment of protein sequences to Pfam domain families with a comparative statistical analysis. Besides comprehensive tabular data files, the CoMet server also provides visually interpretable output in terms of hierarchical clustering and multi-dimensional scaling plots and thus allows a quick overview of a given set of metagenomic samples.
- Issue Date
- 2011
- Status
- published
- Publisher
- Oxford Univ Press
- Journal
- Nucleic Acids Research
- ISSN
- 0305-1048
- Sponsor
- Deutsche Forschungsgemeinschaft [ME3138, LI2050]