Glycine transporter 1 expression in the ventral respiratory group is restricted to protoplasmic astrocytes
2006 | journal article. A publication with affiliation to the University of Göttingen.
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Glycine transporter 1 expression in the ventral respiratory group is restricted to protoplasmic astrocytes
Szoke, K.; Haertel, K.; Grass, D.; Hirrlinger, P. G.; Hirrlinger, J. & Huelsmann, S. (2006)
Brain Research, 1119 pp. 182-189. DOI: https://doi.org/10.1016/j.brainres.2006.08.089
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- Authors
- Szoke, Katalin; Haertel, Kai; Grass, Dennis; Hirrlinger, Petra G.; Hirrlinger, Johannes; Huelsmann, Swen
- Abstract
- The lack of the glycine transporter 1 (GlyT1) leads to early postnatal death due to failure of respiratory network activity. Here we demonstrate a segregated expression of GlyT1 on different astroglial cell populations of the ventral respiratory group. In TgN(hGFAP-EGFP) mice a combined immunohistochemical and electrophysiological approach was used to define the cellular expression of GlyT1 in the respiratory network. EGFP-labeled cells with outwardly rectifying current-voltage relationship did not express glycine transporter 1, while GlyT1 was abundantly expressed in mature protoplasmic astrocytes, which are electrophysiologically characterized by a large potassium conductance, a more negative membrane potential and the expression of glutamate transporters. Taken together, the vital capacity for the clearance of extracellular glycine is restricted to a subpopulation of astroglial cells. (c) 2006 Elsevier B.V. All rights reserved.
- Issue Date
- 2006
- Journal
- Brain Research
- ISSN
- 0006-8993