Neuronal Ca2+ signaling via caldendrin and calneurons
2006 | conference paper. A publication with affiliation to the University of Göttingen.
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Neuronal Ca2+ signaling via caldendrin and calneurons
Mikhaylova, M.; Sharma, Y.; Reissner, C.; Nagel, F.; Aravind, P.; Rajini, B. & Smalla, K.-H. et al. (2006)
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1763(11) pp. 1229-1237. 9th European Symposium on Calcium-Binding Proteins in Normal and Transformed Cells, Ecole Superieure Biotechnol, Strasbourg, FRANCE.
Amsterdam: Elsevier Science Bv. DOI: https://doi.org/10.1016/j.bbamcr.2006.08.047
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Details
- Authors
- Mikhaylova, Marina; Sharma, Yogendra; Reissner, Carsten; Nagel, Falko; Aravind, Penmatsa; Rajini, Bheemreddy; Smalla, Karl-Heinz; Gundelfinger, E. D.; Kreutz, Michael R.
- Abstract
- The calcium sensor protein caldendrin is abundantly expressed in neurons and is thought to play an important role in different aspects of synapto-dendritic Ca2+ signaling. Caldendrin is highly abundant in the postsynaptic density of a subset of excitatory synapses in brain and its distinct localization raises several decisive questions about its function. Previous work suggests that caldendrin is tightly associated with Ca2+ - and Ca2+ release channels and might be involved in different aspects of the organization of the postsynaptic scaffold as well as with synapse-to-nucleus communication. In this report we introduce two new EF-hand calcium sensor proteins termed calneurons that apart from calmodulin represent the closest homologues of caldendrin in brain. Calneurons have a different EF-hand organization than other calcium sensor proteins, are prominently expressed in neurons and will presumably bind Ca2+ with higher affinity than caldendrin. Despite some significant structural differences it is conceivable that they are involved in similar Ca2+ regulated processes like caldendrin and neuronal calcium sensor proteins. (c) 2006 Elsevier B.V. All rights reserved.
- Issue Date
- 2006
- Status
- published
- Publisher
- Elsevier Science Bv
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Conference
- 9th European Symposium on Calcium-Binding Proteins in Normal and Transformed Cells
- Conference Place
- Ecole Superieure Biotechnol, Strasbourg, FRANCE
- ISSN
- 0167-4889