Role of L-DOPA in Spinal Nociceptive Reflex Activity: Higher Sensitivity of A delta Versus C Fibre-Evoked Nociceptive Reflexes to L-DOPA
2011 | journal article. A publication with affiliation to the University of Göttingen.
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- Authors
- Schomburg, Eike D.; Dibaj, Payam; Steffens, Heinz
- Abstract
- The role of L-DOPA in spinal nociceptive reflex activity has been re-evaluated. In high spinal cats, with supraspinal loops being excluded, the onset of reflex facilitation induced by noxious radiant heat is delayed after injection of L-DOPA by 4 to 10 s, i.e. the early component of nociceptive reflex facilitation is blocked, while the late component persisted. Further investigations have shown that the early component of reflex facilitation induced by noxious radiant heat is mediated by A delta-fibres and the late component by C-fibres. Therefore, it can be assumed that L-DOPA, like opioids, preferentially blocks the transmission in nociceptive reflex pathways from A delta-fibres.
- Issue Date
- 2011
- Status
- published
- Publisher
- Acad Sciences Czech Republic, Inst Physiology
- Journal
- PHYSIOLOGICAL RESEARCH
- ISSN
- 0862-8408
- Sponsor
- Deutsche Forschungsgemeinschaft [SCHO 37/16]