Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility
2012 | journal article. A publication with affiliation to the University of Göttingen.
Jump to: Cite & Linked | Documents & Media | Details | Version history
Cite this publication
Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility
Li, M.; Wang, Y. I.; Zheng, X.-b.; Ikeda, M.; Iwata, N.; Luo, X.-j. & Chong, S.-A. et al. (2012)
Schizophrenia Research, 142(1-3) pp. 200-205. DOI: https://doi.org/10.1016/j.schres.2012.10.008
Documents & Media
Details
- Authors
- Li, Ming; Wang, Y. I.; Zheng, Xue-bin; Ikeda, Masashi; Iwata, Nakao; Luo, Xiong-jian; Chong, Siow-Ann; Lee, Jimmy; Rietschel, Marcella; Zhang, Fengyu; Mueller-Myhsok, Bertram; Cichon, Sven; Weinberger, Daniel R.; Mattheisen, Manuel; Schulze, Thomas G.; Martin, Nicholas G.; Mitchell, Philip B.; Schofield, Peter R.; Liu, Jian-jun; Su, Bing
- Abstract
- Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17x10(-4), N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.
- Issue Date
- 2012
- Status
- published
- Publisher
- Elsevier Science Bv
- Journal
- Schizophrenia Research
- ISSN
- 0920-9964
