FOLLISTATIN DOES NOT INFLUENCE THE COURSE OF ESCHERICHIA COLI K1 SEPSIS IN A MOUSE MODEL
2012 | journal article. A publication with affiliation to the University of Göttingen.
Jump to: Cite & Linked | Documents & Media | Details | Version history
Cite this publication
FOLLISTATIN DOES NOT INFLUENCE THE COURSE OF ESCHERICHIA COLI K1 SEPSIS IN A MOUSE MODEL
Diesselberg, C.; Ribes, S.; Michel, U.; Redlich, S.; Brueck, W.; Nau, R. & Schuetze, S. (2012)
Shock, 38(6) pp. 615-619. DOI: https://doi.org/10.1097/SHK.0b013e3182748d96
Documents & Media
Details
- Authors
- Diesselberg, Catharina; Ribes, Sandra; Michel, Uwe; Redlich, Sandra; Brueck, Wolfgang; Nau, Roland; Schuetze, Sandra
- Abstract
- Follistatin (FS) is the binding protein of activin A and inhibits its actions. The activin/FS system participates in the fine tuning of the immune response, and concentrations of activin A and FS are elevated in serum of patients with sepsis. Intraperitoneal injection of FS markedly reduced mortality after lipopolysaccharide-induced inflammation in a mouse model. Here, we investigated whether FS also influences the disease course in a mouse model of sepsis induced by intraperitoneal injection of Escherichia coli K1, a gram-negative bacterium frequently causing septic bacterial infections. Intraperitoneal injection of 10 mu g/mL FS 30 min before infection did not influence survival, weight, motor performance, or bacterial titers of the infected mice. Thus, we could not confirm the protective effect of FS observed during lipopolysaccharide-induced inflammation in our mouse model of E. coli sepsis. Although it is a promising therapeutic tool in chronic or acute inflammatory conditions not caused by virulent pathogens, FS does not seem to increase the resistance to bacterial infections.
- Issue Date
- 2012
- Status
- published
- Publisher
- Lippincott Williams & Wilkins
- Journal
- Shock
- ISSN
- 1540-0514; 1073-2322