Favourable response to plasma exchange in tumefactive CNS demyelination with delayed B-cell response
2012 | journal article. A publication with affiliation to the University of Göttingen.
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Favourable response to plasma exchange in tumefactive CNS demyelination with delayed B-cell response
Seifert, C. L.; Wegner, C.; Sprenger, T.; Weber, M. S.; Brueck, W.; Hemmer, B. & Sellner, J. (2012)
Multiple Sclerosis Journal, 18(7) pp. 1045-1049. DOI: https://doi.org/10.1177/1352458511429012
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Details
- Authors
- Seifert, Christian L.; Wegner, Christiane; Sprenger, Till; Weber, Martin S.; Brueck, Wolfgang; Hemmer, Bernhard; Sellner, Johann
- Abstract
- We report a case of multiple sclerosis-associated fulminant tumefactive demyelinating lesion (TDL) with the special feature of delayed humoral immune response. Plasma exchange (PE) yielded significant benefit in two consecutive steroid-unresponsive relapses, while signs of an intrathecal B-cell response were only present 2 years later at the second relapse. Remission was achieved and sustained thereafter with natalizumab. Our case indicates that PE might be a therapeutic option even when the B-cell response is not fully developed. This delay in the development of a humoral immune response may reflect the step-wise B-cell colonization of the CNS and represent an attractive therapeutic window of opportunity.
- Issue Date
- 2012
- Status
- published
- Publisher
- Sage Publications Ltd
- Journal
- Multiple Sclerosis Journal
- ISSN
- 1352-4585