The Alarmin Interleukin-33 Drives Protective Antiviral CD8(+) T Cell Responses
2012 | Zeitschriftenartikel. Eine Publikation mit Affiliation zur Georg-August-Universität Göttingen.
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Zitiervorschlag
The Alarmin Interleukin-33 Drives Protective Antiviral CD8(+) T Cell Responses
Bonilla, W. V.; Froehlich, A.; Senn, K.; Kallert, S.; Fernandez, M.; Johnson, S. & Kreutzfeldt, M. u.a. (2012)
Science, 335(6071) pp. 984-989. DOI: https://doi.org/10.1126/science.1215418
Dokumente & Medien
Details
- Autor(en)
- Bonilla, Weldy V.; Froehlich, Anja; Senn, Karin; Kallert, Sandra; Fernandez, Marylise; Johnson, Susan; Kreutzfeldt, Mario; Hegazy, Ahmed N.; Schrick, Christina; Fallon, Padraic G.; Klemenz, Roman; Nakae, Susumu; Adler, Heiko; Merkler, Doron; Loehning, Max; Pinschewer, Daniel D.
- Zusammenfassung
- Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also known as damage-associated molecular patterns or alarmins, remains ill defined. We show that interleukin-33 (IL-33), an alarmin released from necrotic cells, is necessary for potent CD8(+) T cell (CTL) responses to replicating, prototypic RNA and DNA viruses in mice. IL-33 signaled through its receptor on activated CTLs, enhanced clonal expansion in a CTL-intrinsic fashion, determined plurifunctional effector cell differentiation, and was necessary for virus control. Moreover, recombinant IL-33 augmented vaccine-induced CTL responses. Radio-resistant cells of the splenic T cell zone produced IL-33, and efficient CTL responses required IL-33 from radio-resistant cells but not from hematopoietic cells. Thus, alarmin release by radio-resistant cells orchestrates protective antiviral CTL responses.
- Erscheinungsdatum
- 2012
- Status
- published
- Herausgeber
- Amer Assoc Advancement Science
- Zeitschrift
- Science
- ISSN
- 0036-8075