CD133 is a predictor of poor survival in head and neck squamous cell carcinomas
2012 | journal article. A publication with affiliation to the University of Göttingen.
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CD133 is a predictor of poor survival in head and neck squamous cell carcinomas
Canis, M.; Lechner, A.; Mack, B.; Zengel, P.; Laubender, R. P.; Koehler, U. & Heissmeyer, V. et al. (2012)
Cancer Biomarkers, 12(2) pp. 97-105. DOI: https://doi.org/10.3233/CBM-130297
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Details
- Authors
- Canis, Martin; Lechner, Axel; Mack, Brigitte; Zengel, Pamela; Laubender, Ruediger Paul; Koehler, Udo; Heissmeyer, Vigo; Gires, Olivier
- Abstract
- BACKGROUND: The pentaspan protein CD133 (Prominin-1) is a predictive marker and part of the signature of tumour-initiating cells (TICs) for various cancer entities. METHODS: The correlation of CD133 expression with clinical parameters was assessed in primary samples of head and neck squamous cell carcinomas (n = 98) and normal mucosas (n = 24). RESULTS: A gradual and inversely proportional correlation between CD133 expression in primary tumours and decreased overall survival was observed, along with a positive correlation with the presence of lymph node metastases. CONCLUSIONS: CD133 has the potential of being a novel clinically relevant prognostic marker for head and neck malignancies, which is possibly involved in regulation of tumourigenicity.
- Issue Date
- 2012
- Status
- published
- Publisher
- Ios Press
- Journal
- Cancer Biomarkers
- ISSN
- 1574-0153
